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Diphenhydramine may also be used for purposes not listed in this diphenhydramine urine drug test guide.n antihistamine with anticholinergic effects; the hydrochloride salt is used for relief of allergic symptoms, for treatment of anaphylaxis, parkinsonism, and motion sickness or other causes of nausea, vomiting, or vertigo, and as an antitussive; administered orally, intramuscularly, or intravenously.

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